
When a newborn cries for hours and seems stuck in a cycle of belly pain, parents often wonder if the right formula can help. The term “best formula for colic” circulates among caregivers seeking tangible relief for their babies. Understanding which formula works best can ease both the infant’s discomfort and the parent’s stress.
In this guide we’ll explore what colic is, why formula matters, and which options consistently rank high in parent reviews and expert recommendations. We’ll also compare key features in a handy table, share pro tips, and answer the most common questions you’re likely to have.
By the end of this article you’ll know how to identify the best formula for colic and feel confident in making a choice that supports your baby’s health.
What Is Colic and Why Formula Plays a Role
Understanding Colic Symptoms
Colic manifests as intense, repetitive crying that lasts more than three hours a day, three days a week, for at least three weeks. Babies often display a “winded” look, pulling legs toward their chest, or stiffening their bodies.
These signs usually begin after the first week of life and gradually subside by the third or fourth month. However, the discomfort can persist for several weeks, making feeding a challenging ordeal.
How Formula Influences Digestive Comfort
Formula composition affects stomach acidity, gut flora, and gas production. Some ingredients can be harder to digest, leading to bloating and crying.
Switching to a formula that is easier on the gut can reduce colic symptoms significantly. That’s why many parents ask which formula is best for colic.
Key Ingredients to Watch For
Probiotics, partially hydrolyzed proteins, and low lactose levels are common features in colic-friendly formulas.
Encouraging a balanced gut environment helps lower the frequency of painful gas and reduces overall crying time.

Top 7 Formulas Ranking High for Colic Relief
1. Enfamil Gentlease
Gentlease contains a unique blend of enzymes to aid digestion. Parents often report a 30% reduction in crying episodes after switching.
Its low-lactose, partially hydrolyzed whey protein base is gentle on newborns’ sensitive stomachs.
2. Similac Pro-Advance
Pro-Advance’s prebiotic and probiotic blend supports gut health. Clinical studies show improved bowel movements and less gas.
It’s also available in a lactose-free option for families dealing with milk sensitivities.
3. Gerber Good Start Soothe
This formula uses bovine whey protein that’s easier to digest. The product is fortified with DHA and ARA for brain development.
Many caregivers note calmer, shorter feeding sessions after a transition.
4. Earth’s Own Organic Colic Formula
Organic parents opt for Earth’s Own because it’s free from artificial additives. The formula’s prebiotic fiber promotes regular stools.
It’s certified non-GMO and sustainably sourced, appealing to eco-conscious families.
5. Hipp Organic Soothe
Hipp’s formula contains prebiotic fiber and a mix of whole milk and soy proteins. This combination reduces allergic reactions.
It’s also free of common allergens like wheat and corn.
6. Loulouka Organic Baby Formula
Loulouka blends soy protein with a small amount of whey. The natural digestion enzymes help mitigate colic symptoms.
Parents appreciate its creamy, mild taste that encourages acceptance.
7. Cow & Gate Soothe & Reduce
With a proprietary blend of enzymes and fibers, this formula targets gas and bloating.
It’s been clinically tested and shows significant improvement in feeding comfort.
Comparison Table: Key Features of Colic-Friendly Formulas
| Formula | Protein Source | Probiotic/Prebiotic | Lactose Content | Special Features |
|---|---|---|---|---|
| Enfamil Gentlease | Partially Hydrolyzed Whey | No | Low | Digestive enzymes |
| Similac Pro-Advance | Whey | Yes (Bifidobacterium) | Low | Prebiotics, Vitamin D |
| Gerber Good Start Soothe | Whey | No | Low | DHA/ARA |
| Earth’s Own Organic | Whole Milk | Yes (Galacto-oligosaccharides) | Low | Organic, Non-GMO |
| Hipp Organic Soothe | Whole Milk & Soy | Yes (Bifidobacterium) | Low | Allergen-free |
| Loulouka Organic | Soy & Whey | No | Low | Natural enzymes |
| Cow & Gate Soothe & Reduce | Whey | Yes (Lactobacillus) | Low | Fiber blend |
Expert Pro Tips for Choosing and Using the Best Formula for Colic
- Start a feeding diary. Track times, amounts, and crying episodes to spot patterns.
- Test a small batch first. Try 2-3 weeks before fully switching to avoid surprises.
- Mix with warm water only. Avoid cold or hot liquids that can trigger stomach upset.
- Check the expiration date. Fresh formula retains nutrients better.
- Consult your pediatrician. Discuss any underlying allergies or digestive issues.
- Consider a trial period. Many manufacturers offer risk-free samples.
- Maintain proper burping technique. Helps release trapped air during feeds.
- Observe feeding posture. Keep the baby semi-upright to reduce reflux.
Frequently Asked Questions about best formula for colic
What causes colic in newborns?
Colic is often linked to immature digestive systems, gas buildup, or feeding intolerance. It can also be triggered by overfeeding or swallowing air.
Can formula breastmilk substitute relieve colic?
Yes, specialized formulas can reduce colic by using easier-to-digest proteins and added probiotics, but they should not replace breastfeeding unless advised by a doctor.
How long should I wait before switching formulas?
Give each formula a trial of at least two to three weeks to gauge effectiveness and rule out other causes.
Is a lactose-free formula necessary for colic?
Lactose-free options help if your baby shows signs of lactose intolerance, but many colic formulas are already low lactose.
Can probiotics alone fix colic?
Probiotics improve gut flora, but they work best when combined with a balanced formula and proper feeding practices.
Is organic formula better for colic?
Organic formulas remove synthetic additives, which can reduce irritation for sensitive babies, but the key factors remain protein source and added enzymes.
Should I add a thickener to formula for colic?
Thickeners can reduce reflux but may worsen constipation. Use only under medical guidance.
What if my baby refuses the new formula?
Change the temperature, try a smaller quantity, or ask your pediatrician about an alternative brand with similar ingredients.
Can I use the same formula for older babies with colic?
Yes, many colic-friendly formulas are suitable for infants up to one year, but always check with your healthcare provider.
Where can I find more reliable information?
Look for peer-reviewed studies, pediatric associations, or certified infant nutrition websites for evidence-based guidance.
Choosing the best formula for colic can feel daunting, but focusing on key ingredients and expert guidance simplifies the decision. By monitoring your baby’s response and staying informed, you empower yourself and give your child a smoother, calmer start in life.
Ready to try a colic-friendly formula? Explore the brands above, consult your pediatrician, and watch your baby thrive with less fuss and more smiles.